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Investigating the genetic relationship between vitamin B12 deficiency and Parkinson's disease

2025-01-02 neurology Title + abstract only
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IntroductionEpidemiological studies suggest that patients with Parkinsons disease (PD) may have lower levels of vitamin B12 compared to healthy controls, and it was proposed that PD patients could benefit from vitamin B12 supplementation. Functional studies have shown that B12 could modify LRRK2 activity and may directly interact with alpha-synuclein. This study aimed to investigate the role of common and rare variants in genes related to B12 metabolism and assess the potential causal relationsh...

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