Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice
Evans, M. M.; Hing, B. W. Q.; Weber, M. A.; Maurer, S. V.; Baig, A. I.; Kim, G. S.; Anema, S. L.; Ellerbroek, R. M.; Sivakumar, K.; Michaelson, J. J.; Narayanan, N. S.; Stevens, H. E.
Show abstract
Maternal stress during pregnancy, or prenatal stress, is a risk factor for neurodevelopmental disorders in offspring, including autism spectrum disorder (ASD). In ASD, dorsal striatum displays abnormalities correlating with symptom severity, but there is a gap in knowledge about dorsal striatal cellular and molecular mechanisms that may contribute. Using a mouse model, we investigated how prenatal stress impacted striatal-dependent behavior in adult offspring. We observed enhanced motor learning and earlier response times on an interval timing task, with accompanying changes in time-related medium spiny neuron (MSN) activity. We performed adult dorsal striatal single-cell RNA sequencing following prenatal stress which revealed differentially expressed genes (DEGs) in multiple cell types; downregulated DEGs were enriched for ribosome and translational pathways consistently in MSN subtypes, microglia, and somatostatin neurons. DEGs in MSN subtypes over-represented ASD risk genes and were enriched for synapse-related processes. These results provide insights into striatal alterations relevant to neurodevelopmental disorders.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Targeted Tshz3 deletion in corticostriatal circuit components segregates core autistic behaviors 97%
- Meta-analysis of the brain transcriptomes of multiple genetic mouse models of schizophrenia highlights dysregulation in striatum and thalamus 95%
- adgrl3.1-deficient zebrafish show noradrenaline-mediated externalizing behaviors, and altered expression of externalizing disorder-candidate genes, suggesting functional targets for treatment 95%
Similar papers in this journal
- Multi-parametric assays capture sex- and environment-dependent modifiers of behavioral phenotypes in autism mouse models 95%
- Chronic stress exposure alters the gut barrier: sex-specific effects on microbiota and jejunum tight junctions 95%
- Partial or complete loss of norepinephrine differentially alters contextual fear and catecholamine release dynamics in hippocampal CA1 94%
Similar papers in this journal
- Prefrontal allopregnanolone mediates the adverse effects of acute stress in a mouse model of tic pathophysiology 96%
- Perinatal exposure to fluoxetine and maternal adversity affect myelin-related gene expression and epigenetic regulation in the corticolimbic circuit of juvenile rats 95%
- Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions 95%
Similar papers in this journal
- Serotonin sensing by microglia conditions the proper development of neuronal circuits and of social and adaptive skills 96%
- Hippocampal area CA2 activity supports social investigation following an acute social stress. 95%
- Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposure 95%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.