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A 3D ovarian cancer metastasis model using a decellularized peritoneal matrix to study therapy response
2024-12-29
oncology
Title + abstract only
View on medRxiv
Show abstract
High-grade serous ovarian carcinoma (HGSOC) presents a significant therapeutic challenge. Late-stage disease is frequently associated with peritoneal carcinomatosis. The peritoneal metastases exhibit a unique tumor microenvironment (TME) distinct from the primary tumors and other metastatic sites. Understanding the critical influence of the extracellular matrix (ECM) in shaping the tumor phenotype is essential for the development of effective new therapies. This study introduces a novel three-di...
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