Back

Species-specific oxygen sensing governs the initiation of vertebrate limb regeneration

Tsissios, G.; Leleu, M.; Hu, K.; Demirtas, A. E.; Hu, H.; Kawanishi, T.; Skoufa, E.; Valente, A.; Herrera, A.; Mery, A.; Noseda, L.; Ochi, H.; Sakar, S.; Tanaka, M.; Zenk, F.; Aztekin, C.

2024-12-20 developmental biology
10.1101/2024.12.19.629359 bioRxiv
Show abstract

Why mammals cannot regenerate limbs, unlike amphibians, presents a longstanding puzzle in biology. We show that exposing ex vivo amputated embryonic mouse limbs to subatmospheric oxygen environment, or stabilizing oxygen-sensitive HIF1A enables not only rapid wound healing, but alters cellular mechanics, and reshapes the histone landscape to prime regenerative fates. Conversely, regenerative Xenopus tadpole limbs display low oxygen-sensing capacity, robust wound healing, a regenerative histone landscape, and glycolytic programs even under high oxygen. This reduced oxygen-sensing capacity, in stark contrast to mammals, associates with decreased HIF1A-regulating gene expressions. Our findings thus uncover species-specific oxygen sensing as a unifying mechanism for limb regeneration initiation across vertebrates, reveal how aquatic subatmospheric habitats may enhance regenerative capabilities, and identify targetable barriers to unlock latent limb regenerative programs in adult mammals.

Published in Science (predicted rank #5) · training set

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

1
Developmental Cell
○ 196 papers in training set
Top 0.1%
26.2%
Similar papers in this journal
2
Science Advances
● 1243 papers in training set
Top 0.2%
18.2%
Similar papers in this journal
3
Nature Communications
○ 5641 papers in training set
Top 18%
9.6%
Similar papers in this journal
50% of probability mass above
4
Proceedings of the National Academy of Sciences
● 2444 papers in training set
Top 5%
7.8%
Similar papers in this journal
Science · published here
● 477 papers in training set
Top 2%
4.3%
Similar papers in this journal
6
Cell Stem Cell
○ 62 papers in training set
Top 0.4%
4.0%
7
Cell Reports
○ 1498 papers in training set
Top 10%
4.0%
8
eLife
● 5828 papers in training set
Top 31%
4.0%
9
Cell
○ 431 papers in training set
Top 4%
2.4%
10
npj Regenerative Medicine
○ 24 papers in training set
Top 0.3%
2.1%
11
iScience
○ 1154 papers in training set
Top 14%
2.1%
12
Development
● 497 papers in training set
Top 3%
1.7%
13
Nature
○ 645 papers in training set
Top 8%
1.4%
14
Current Biology
○ 665 papers in training set
Top 8%
1.1%
15
Nature Cell Biology
○ 118 papers in training set
Top 3%
1.0%
16
Matrix Biology
○ 29 papers in training set
Top 0.7%
0.8%
17
The EMBO Journal
○ 309 papers in training set
Top 6%
0.8%
18
Advanced Science
○ 286 papers in training set
Top 11%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.