Molecular mechanisms of heart field specific cardiomyoscytedifferentiation- a computational modeling approach
Argyris, G.; Zeegelaar, R. A.; Post, J. N.
Show abstract
Tissue engineering protocols achieve building miniature hearts but mechanisms determining cell differentiation still need to be fully understood and optimized. In this study, we present a gene regulatory network (GRN) that describes the differentiation of committed cardiomyocytes towards ventricular or atrial cardiomyocytes. The GRN is coupled with Boolean dynamics and steady state analysis shows steady states which agree with the experimental expression of marker genes. Our Boolean model extends earlier work on a model describing the first and second heart field formation to include atrial and ventricular cardiomyocytes. Thus, our study paves the way for the generation of heart field-specific cardiomyocytes located in specific chambers of the fully developed heart. The Boolean model is validated through simulations and by its ability to reproduce known knockouts.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
Similar papers in this journal
- Preponderance of generalized chain functions in reconstructed Boolean models of biological networks 95%
- Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells. 95%
- Determining Interaction Directionality in Complex Biochemical Networks from Stationary Measurements 95%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.