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Brain Ischemia in Alzheimer's disease counteracts the Disruption of the Blood Brain Barrier: A Hypothesis Investigated with a Lumped Parameter Model.

2024-12-20 geriatric medicine Title + abstract only
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BackgroundIn normal pressure hydrocephalus (NPH) there is blood brain barrier (BBB) disruption, which should increase the CSF formation rate (CSFfr) and therefore the intracranial pressure (ICP). However, the ICP is normal in NPH. A lumped parameter study suggested that the CSFfr could be reduced in this condition if the BBB disruption was moderated by a reduction in the capillary transmural pressure (TMP) secondary to arteriolar constriction. In early Alzheimers disease (AD), there is BBB disru...

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