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Effectiveness of a single dose of oral cholera vaccine: findings from epidemiological and genomic surveillance of Vibrio Cholerae in the Democratic Republic of the Congo (PICHA7 Program)
2024-12-16
infectious diseases
Title + abstract only
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This study investigated whole-cell oral cholera vaccine (kOCV) single-dose effectiveness and transmission dynamics of Vibrio cholerae through 4 years of epidemiological and genomic surveillance in Democratic Republic of the Congo (DRC). Whole genome sequencing was performed on clinical and water V. cholerae strains from 200 patient households and found annual bimodal peaks of V. cholerae clade AFR10e. 1154 diarrhea patients were enrolled with 342 culture confirmed cholera patients. A large clona...
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