Widespread genetic testing control inherited polycystic kidney disease in cats
Ukawa, H.; Kida, A.; Ataka, K.; Horie, R.; Matsumoto, Y.
Show abstract
A genetic variant of PKD1 in cats, which causes polycystic kidney disease (PKD), is a target for direct-to-consumer genetic testing to assess PKD risk; however, its effect on genetic structure in cat populations remains unexplored. Therefore, in this study, we aimed to examine the changes in feline PKD and the PKD1 variant across breeds and over time using a large dataset of 110,325 insured and 61,968 genetic-tested cats from 14 breeds. Results revealed that the PKD1 variant frequency significantly decreased, with a reduction of 42.6% before 2019 and after 2022. Systematic genomic analysis revealed no differences in genetic structure or inbreeding levels. The effective population size of cats with the PKD1 variant decreased between points. Overall, these findings highlight the potential of direct-to-consumer genetic testing in promoting more optimized breeding practices and enhancing feline welfare.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Genetic epidemiology of blood type, disease and trait variants, and genome-wide genetic diversity in over 11,000 domestic cats 97%
- Genetic prevalence and clinical relevance of canine Mendelian disease variants in over one million dogs 96%
- IP3 receptor depletion in a spontaneous canine model of Charcot-Marie-Tooth disease 1J with amelogenesis imperfecta 94%
Similar papers in this journal
- Diverse Species-Specific Phenotypic Consequences of Loss of Function Sorting Nexin 14 Mutations 90%
- Prevalence of pathogenic variants in DNA damage response genes in patients undergoing cancer risk assessment and reporting a personal history of early-onset renal cancer 89%
- New C3H KitN824K/WT cancer mouse model develops late-onset malignant mammary tumors with high penetrance 89%
Similar papers in this journal
- A community-science approach identifies genetic variants associated with three color morphs in ball pythons (Python regius) 92%
- Dog Size and Patterns of Disease History Across the Canine Age Spectrum: Results from the Dog Aging Project 91%
- True Colors: commercially-acquired morphological genotypes reveal hidden allele variation among dog breeds, informing both trait ancestry and breed potential 91%
Similar papers in this journal
- Genomic analyses identify 15 susceptibility loci and reveal HDAC2, SOX2-OT, and IGF2BP2 in a naturally-occurring canine model of gastric cancer 91%
- White-tailed deer (Odocoileus virginianus) may serve as a wildlife reservoir for nearly extinct SARS-CoV-2 variants of concern 91%
- Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits 91%
Similar papers in this journal
- A 1-bp deletion in bovine QRICH2 causes low sperm count and immotile sperm with multiple morphological abnormalities 90%
- Size and composition of haplotype reference panels impact the accuracy of imputation from low-pass sequencing in cattle 90%
- Cost-effectively dissecting the genetic architecture of complex wool traits in rabbits by low-coverage sequencing 89%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.