Genomic diversity of the African malaria vector Anopheles funestus
Bodde, M.; Nwezeobi, J.; Korlevic, P.; Makunin, A.; Akone-Ella, O.; Barasa, S.; Gadji, M.; Hart, L.; Kaindoa, E. W.; Love, K.; Lucas, E. R.; Lujumba, I.; Maquina, M.; Nagi, S.; Odero, J. O.; Polo, B.; Sangbakembi, C.; Dadzie, S.; Koekemoer, L. L.; Kwiatkowski, D.; McAlister, E.; Ochomo, E.; Okumu, F.; Paaijmans, K.; Tchouassi, D. P.; Wondji, C. S.; Ayala, D.; Durbin, R.; Miles, A.; Lawniczak, M. K.
Show abstract
Anopheles funestus s.s. is a formidable human malaria vector across sub-Saharan Africa. To understand how the species is evolving, especially in response to malaria vector control, we sequenced 656 modern specimens (collected 2014-2018) and 45 historic specimens (collected 1927-1967) from 16 African countries. We find high levels of genetic variation with clear and stable continental patterns. Six segregating inversions might be involved in adaptation of local ecotypes. Strong recent signals of selection centred on canonical insecticide resistance genes are shared by multiple populations. A promising gene drive target in An. gambiae is highly conserved in An. funestus. This work represents a significant advance in our understanding of the genetic diversity and population structure of An. funestus and will enable smarter targeted malaria control.
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