Putative neofunctionalization of a Poales-specific EXO70 clade
Bergum, M.; Sklenar, J.; Hernandez-Pinzon, I.; Taylor, J.; Smoker, M.; Samwald, S.; Allen, M.; Thind, A.; Green, P.; Moon, H.; Menke, F. L. H.; Zipfel, C.; Rhodes, J.; Faulkner, C.; Moscou, M. J.
Show abstract
EXO70s are uniquely expanded in land plants compared to all other eukaryotic lineages. The functional implications of this expansion and diversification on the conserved role of EXO70 as a subunit of the octameric exocyst complex have remained unresolved. We previously demonstrated barley (Hordeum vulgare) EXO70FX12, a member of the monocot-specific EXO70FX clade, is required for resistance to wheat stripe rust in conjunction with the leucine-rich repeat receptor kinase (LRR-RK) HvPUR1. Through phylogenetic analysis, we identified unique features of the EXO70FX clade, leading us to hypothesize that this clade experienced neofunctionalization. Using structural predictions and protein-protein interaction assays, we demonstrate that HvEXO70FX12 lost the ability to serve as a subunit within the exocyst complex. We predict that the EXO70FX clade has largely lost exocyst association and represents a novel acquisition that emerged during Poales diversification for immunity.
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