MIND-Map; A Comprehensive Toolbox for Estimating Brain Dynamic States
Khodaei, M.; Laurienti, P. J.; Simpson, S. L.; Shappell, H. M.
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Studying dynamic brain states has offered new insights into understanding functional connectivity. One of the promising approaches for estimating these brain states is the hidden semi-Markov model (HSMM). However, despite its potential, its adoption in the neuroscience community has been limited due to its complexity. We developed the Markov Inference Dynamic Mapping (MIND-Map) toolbox to overcome this limitation. This interactive user-friendly toolbox leverages HSMM to identify brain states, analyze their dynamics, and perform two-sample statistical comparisons of network dynamics. Furthermore, it introduces a new approach, not yet used in conjunction with these models, for determining the optimal number of states, addressing a key challenge in the field. We assessed the performance of the HSMM and our method for identifying the optimal number of states using two datasets, including a unique dataset explicitly developed for this purpose.
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