Modulation of Purkinje Cell Inhibition by Stem Cell Factor
Zaman, T.; Lahr, J.; Cherian, S.; Pozzo-Miller, L.; Williams, M. R.
Show abstract
Abstract / SummaryTarget derived factors influence the specification, maintenance, and modulation of synaptic connectivity. The transmembrane protein, Kit Ligand, and Kit receptor tyrosine kinase are differentially expressed in connected neurons. In development and postnatal periods, these proteins maintain connectivity between cerebellar Purkinje cells (PC) that express Kit Ligand, and presynaptic Molecular Layer Interneurons (MLI) expressing Kit. In this study, it is demonstrated that Stem Cell Factor (SCF), the active extracellular domain of Kit Ligand, produces a potent potentiation of inhibition upon Purkinje Cells. The SCF enhancement of inhibition required presynaptic Kit, produced long term suppression of PC firing, and was associated with a specific potentiation of basket cells of the MLI1 subtype. It is posited that SCF exerts a postsynaptic effect involving enhanced sensitivity of somatic PC GABAA receptors. This work demonstrates that the SCF/Kit axis modulates synaptic function in adult tissue.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in CA3 circuit 95%
- Dissociation of SYNGAP1 Enzymatic and Structural Roles: Intrinsic Excitability and Seizure Susceptibility 93%
- The autism-associated loss of δ-catenin functions disrupts social behaviors 93%
Similar papers in this journal
- Acetylcholine modulates cerebellar granule cell spiking by regulating the balance of synaptic excitation and inhibition 94%
- Differential Activity-Dependent Increase in Synaptic Inhibition and Parvalbumin Interneuron Recruitment in Dentate Granule Cells and Semilunar Granule Cells 94%
- Cholinergic activation of corticofugal circuits in the adult mouse prefrontal cortex 94%
Similar papers in this journal
- Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje Cells 96%
- Inhibitory ultrapotent chemogenetics activate dopamine D1 receptor-expressing medium spiny neurons 94%
- Robust perisomatic GABAergic self-innervation inhibits basket cells in the human and mouse supragranular neocortex 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.