Differential control of mycobacteria among COVID-19 patients is associated with CD28+ CD8+ T cells
Llibre, A.; Siddiqui, H.; Pillaye, J.; Burel, J.; Jones, C.; Hill, H.; Faustini, S. E.; Windle, E.; Karim, H.; Sherry, E.; Green, C. A.; Dedicoat, M.; Stamataki, Z.; Cunningham, A. F.; O'Shea, M. K.
Show abstract
Diseases caused by SARS-CoV-2 and Mycobacterium tuberculosis (M.tb) represent two public health emergencies. In severe disease, both pathogens may share a biological niche in the lower respiratory tract. There is significant potential for SARS-CoV-2 and M.tb infections to be co-present within individuals and enhance or moderate the respective outcomes of either infection. Here, we investigated how whole blood samples, as well as CD4+ and CD8+ T cells, from individuals hospitalised with acute COVID-19 disease respond to mycobacterial challenge. To do this, samples were assessed by ex vivo mycobacterial growth inhibition assays, immune cell phenotyping by mass cytometry, and whole blood cytokine responses to mycobacterial antigens assessed by flow cytometry. These studies identified a subgroup of COVID-19 patients whose blood had an enhanced capacity to inhibit mycobacterial growth. The ability to control mycobacterial growth was associated with the presence of a non M.tb-specific CD28+ CD8+ T cell population, with a particular activation status and migratory phenotype. This work improves our understanding of factors involved in mycobacterial control, and may contribute to the design of novel therapies for TB.
Matching journals
The top 7 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Early and Delayed STAT1-Dependent Responses Drive Local Trained Immunity of Macrophages in the Spleen 95%
- An evolutionary recent IFN-IL-6-CEBP axis is linked to monocyte expansion and tuberculosis severity in humans 95%
- Prolonged T-cell activation and long COVID symptoms independently associate with severe disease at 3 months in a UK cohort of hospitalized COVID-19 patients 95%
Similar papers in this journal
- Metformin enhances anti-mycobacterial responses by educating immunometabolic circuits of CD8+ T cells 96%
- Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow 96%
- Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19 96%
Similar papers in this journal
- A single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients 96%
- Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses 96%
- Dysregulated immune responses in COVID-19 patients correlating with disease severity and invasive oxygen requirements 96%
Similar papers in this journal
- SARS-CoV-2 genome-wide mapping of CD8 T cell recognition reveals strong immunodominance and substantial CD8 T cell activation in COVID-19 patients 95%
- CD36 family members are TCR-independent ligands for CD1 antigen-presentingmolecules 95%
- Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells. 94%
Similar papers in this journal
- Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages 94%
- Aging and viral evolution impair immunity against dominant pan-coronavirus-reactive T cell epitope 94%
- Mobilization of tissue-resident memory CD4+ T lymphocytes and their contribution to a systemic secondary immune reaction 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.