Back

Lifespan trajectory of chimpanzee brains characterized by magnetic resonance imaging histology

Lipp, I.; Kirilina, E.; Jaeger, C.; Morawski, M.; Jauch, A.; Pine, K. J.; Edwards, L. J.; Helbling, S.; Rose, D.; Helms, G.; Eichner, C.; Deschner, T.; Graessle, T.; EBC consortium, ; Gunz, P.; Anwander, A.; Friederici, A. D.; Wittig, R. M.; Crockford, C.; Weiskopf, N.

2024-12-08 neuroscience
10.1101/2024.12.06.627145 bioRxiv
Show abstract

Chimpanzee brain maturation provides an invaluable framework for understanding the evolution of the human brain. We performed ultra-high resolution quantitative magnetic resonance imaging (qMRI) with histological validation on post mortem brains from captive and wild chimpanzees with a broad age range. We mapped developmental myelination and age-related iron accumulation across regions and layers of the neocortex. Compared to humans, chimpanzees showed more myelination and iron deposition in motor and premotor cortices, while the auditory cortex was more strongly myelinated in humans. Our model suggests that chimpanzees cortical myelination was largely completed by the age of nine years, while iron accumulation continued throughout the lifespan. The regions with highest adult levels of myelin and iron took the longest to mature, challenging the widespread assumption that highly myelinated regions complete their development first. The reported maps and developmental curves provide a foundation for comparative neuroscience research and understanding of human brain evolution.

Matching journals

The top 3 journals account for 50% of the predicted probability mass.

1
Nature Communications
○ 5641 papers in training set
Top 2%
34.2%
Similar papers in this journal
2
Communications Biology
○ 993 papers in training set
Top 0.1%
11.9%
Similar papers in this journal
3
Scientific Reports
○ 3612 papers in training set
Top 7%
7.9%
Similar papers in this journal
50% of probability mass above
4
NeuroImage
○ 903 papers in training set
Top 2%
7.9%
Similar papers in this journal
5
eLife
● 5828 papers in training set
Top 17%
6.7%
Similar papers in this journal
6
Scientific Data
○ 209 papers in training set
Top 0.5%
4.8%
7
Science Advances
● 1243 papers in training set
Top 7%
4.3%
8
Imaging Neuroscience
● 282 papers in training set
Top 3%
1.7%
9
Nature
○ 645 papers in training set
Top 7%
1.7%
10
Nature Neuroscience
○ 252 papers in training set
Top 4%
1.5%
11
Cell Reports
○ 1498 papers in training set
Top 21%
1.4%
12
Human Brain Mapping
○ 329 papers in training set
Top 3%
1.3%
13
iScience
○ 1154 papers in training set
Top 36%
0.8%
14
Journal of Cerebral Blood Flow & Metabolism
○ 42 papers in training set
Top 0.8%
0.8%
15
The Journal of Neuroscience
● 1025 papers in training set
Top 10%
0.8%
16
PLOS Biology
● 486 papers in training set
Top 11%
0.8%
17
Brain Communications
◐ 166 papers in training set
Top 4%
0.8%
18
Advanced Science
○ 286 papers in training set
Top 11%
0.6%
19
Brain
◐ 168 papers in training set
Top 4%
0.6%
20
Aperture Neuro
● 20 papers in training set
Top 0.6%
0.6%
21
Progress in Neurobiology
○ 47 papers in training set
Top 1%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.