Concurrent mapping of Electrical, Chemical, and Functional Neuroactivity

Understanding the complex mechanism of human brain function requires innovative approaches that capture the intricate interplay of electrical, chemical, and hemodynamic activities. We developed the PMEEN system, named for its concurrent integration of PET, MRI, EEG, Eye Tracking, and fNIRS modalities by successfully addressing the electromagnetic and gamma ray interference among these modalities and incorporation of centralized clock control to allow simultaneous spatial registration and temporal synchronization. Here we show that PMEEN enables the concurrent acquisition of metabolic, structural, electrical, hemodynamic, and behavioral data, providing a comprehensive view of brain function that was previously inaccessible. By successfully validating the system in healthy volunteers and clinical cases involving patients with major depressive disorder, Alzheimers disease, and epilepsy, we demonstrate its potential for advancing both research and clinical diagnostics. These findings represent a significant technological step forward in neuroimaging, allowing for a holistic understanding of the neural mechanisms underlying cognition and neurological disorders, and setting the stage for future breakthroughs in brain research and therapy. SummaryWe introduce the PMEEN system, a groundbreaking multi-modal neuroimaging platform integrating PET, MRI, EEG, Eye tracking, and fNIRS. This system allows concurrent acquisition of metabolic, structural, electrical, hemodynamic, and behavioral data, providing unprecedented insights into brain function. Through advanced electromagnetic compatibility design and synchronized data acquisition, PMEEN overcomes the technical challenges of integrating these modalities. Validated in phantom, healthy volunteers and patients with major depressive disorder, Alzheimers disease, and epilepsy, PMEEN has demonstrated its capability for capturing comprehensive neural dynamics. This system paves the way for new research opportunities and clinical applications in neurological and psychiatric diagnostics.