DynaMAP: Dynamic Microbiome Abundance Profiling through high density optical mapping
Abakumov, S.; Ruppeka-Rupeika, E.; Chen, X.; Engelbrecht, M.; Mestdagh, I.; D'Huys, T.; Mlodzinska, A.; Leen, V.; Szymanek, A.; Badola, A.; Lukes, T.; Demuyser, T.; Hofkens, J.; Dedecker, P.; Bouwens, A.
Show abstract
Microbial abundance profiling is rapidly becoming an essential method in biomedical research, though it is often costly and time intensive. We present DynaMAP, a rapid approach for microbiome profiling that uses single-molecule imaging to develop an optical map of metagenomic DNA. DynaMAP achieves strain-level taxonomic profiling without requiring base-by-base sequencing and with a one-day turnaround time. In doing so, it delivers microbiome profiling that is comparable to shotgun sequencing but operates more efficiently, strongly expanding the possibility for microbiome analysis.
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