Regulation of B cell migration to the Bursa of Fabricius by CCR7 and cell adhesion molecules in chicken embryonic development
Brunner, M.; Cavaleiro, C. L. C. T.; Berghof, T. V. L.; Wurmser, C.; Elleder, D.; von Heyl, T.; Schusser, B.
Show abstract
The development of functional B lymphocytes during chicken embryogenesis relies on a series of tightly regulated processes. Precursor B cells migrate from the spleen via the blood to the bursa of Fabricius, where they colonize the bursal follicles to undergo further maturation and differentiation. To better understand the molecular mechanisms underlying early B cell migration in the chicken embryo, transcriptome analysis of B cells isolated from the spleen, blood, and bursa at embryonic days (ED) 12, ED14, and ED16 was performed. These findings suggest that sphingosine-1-phosphate (S1P) and its receptors regulate B cell presence in the bloodstream, while CCR7 and CXCR4 guide B cells to the bursa. Additionally, integrins and cell adhesion molecules, such as PECAM1, appear to facilitate transendothelial migration into the bursal mesenchyme. This study highlights a coordinated interplay between chemokines, integrins and cell adhesion molecules involved in B cell recruitment and colonization of the bursa microenvironment. These findings enhance our understanding of early B cell migration and shed light on the mechanisms governing B cell trafficking during chicken embryonic development.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Transcriptional Regulatory Logic Orchestrating Lymphoid and Myeloid Cell Fate Decisions 94%
- Single-cell transcriptomics reveals striking heterogeneity and functional organization of dendritic and monocytic cells in the bovine mesenteric lymph node 93%
- Single cell RNA-sequencing of feline peripheral immune cells with V(D)J repertoire and cross species analysis of T lymphocytes 93%
Similar papers in this journal
- Delayed processing of blood samples impairs the accuracy of mRNA-based biomarkers 94%
- Prediction of sex-determination mechanisms in avian primordial germ cells using RNA-seq analysis 93%
- Single cell transcriptomics delineates the immune-cell landscape in equine lower airways and reveals upregulation of the FKBP5 gene in horses with asthma 93%
Similar papers in this journal
- Single-cell transcriptome analysis of the zebrafish embryonic trunk 95%
- Hematological and gene co-expression network analyses of high-risk beef cattle defines immunological mechanisms and biological complexes involved in bovine respiratory disease and weight gain 94%
- Comparative analysis of transcriptomic profiles among ascidians, zebrafish, and mice: insights from tissue-specific gene expression 94%
Similar papers in this journal
- Hematopoietic growth factors Regulate Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5 94%
- DOT1L methyltransferase regulates the calcium influx in erythroid progenitor cells in response to erythropoietin 94%
- Multi-omics profiling reveals phenotypic and functional heterogeneity of neutrophils in COVID-19 93%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.