Adult visual deprivation engages associative, presynaptic plasticity of thalamic input to cortex
Murase, S.; Severin, D.; Dye, L.; Mesik, L.; Moreno, C.; kirkwood, a.; Quinlan, E. M.
Show abstract
Age constrains plasticity at inputs from first order thalamic nuclei to the cortex, endowing stability to ascending, feed-forward projections. However, here we show that prolonged visual deprivation can induce robust and reversible plasticity at thalamocortical synapses in layer 4 pyramidal neurons in the adult mouse primary visual cortex. The plasticity engaged by prolonged visual deprivation is non-homeostatic and mediated by changes in presynaptic function.
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