A novel Candida glabrata protein regulated by mating signaling pathway shapes inter-species interaction
Parnandi, V. A.; Trivedi, P. M.; Panchal, H.; Patkar, R. N.
Show abstract
During mixed-species invasive candidiasis - an emerging threat in healthcare - presence of Candida albicans is near-essential for host colonisation by C. glabrata. However, the molecular communication underlying such intriguing inter-species interaction is largely unexplored. Here, we show that C. glabrata secretes a unique small protein Yhi1 that induces hyphal growth in C. albicans, which is essential for host tissue invasion. Notably, this Yhi1-based inter-species interaction is specific to C. glabrata and C. albicans, when compared with other common species of Candida. Our structure-function analyses reveal a novel functional pentapeptide motif (AXVXH) required for the function of Yhi1. Interestingly, Yhi1 expression and efflux are regulated through the mating MAPK signalling pathway and the pheromone transporter CgSte6, respectively, in C. glabrata, despite its preferred asexual reproduction. Our findings shed light on how C. glabrata mating signalling pathway is repurposed to interact with C. albicans, and highlight the potential of Yhi1 as a biomarker and a template for a synthetic novel antifungal peptide.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Transient mitochondria dysfunction confers fungal cross-resistance between macrophages and fluconazole 96%
- Aspergillus fumigatus G-protein coupled receptors GprM and GprJ are important for the regulation of the cell wall integrity pathway, secondary metabolite production, and virulence 95%
- Screening of chemical libraries for new antifungal drugs against Aspergillus fumigatus reveals the potential mechanism of action of miltefosine 95%
Similar papers in this journal
- Glycolysis-dependent Sulfur Metabolism Orchestrates Morphological Plasticity and Virulence in Fungi 96%
- Hülle-cell-mediated protection of fungal reproductive and overwintering structures against fungivorous animals 96%
- Temporal transcriptional response of Candida glabrata during macrophage infection reveals a multifaceted transcriptional regulator CgXbp1 important for macrophage response and drug resistance 95%
Similar papers in this journal
- The pre-mRNA Splicing Modulator Pladienolide B Inhibits Cryptococcus neoformans Germination and Growth 95%
- A conserved machinery underlies the synthesis of a chitosan layer in the Candida chlamydospore cell wall 94%
- The adaptive role of cell death in yeast communities stressed with macrolide antifungals 94%
Similar papers in this journal
- Real-time visualization of phagosomal pH manipulation by Cryptococcus neoformans in an immune signal-dependent way 93%
- Expression of a Malassezia codon optimized mCherry fluorescent protein in a bicistronic vector 93%
- Stage-Specific MCM Protein Expression in Trypanosoma cruzi: Insights Into Metacyclogenesis and G1 Arrested epimastigotes. 92%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.