Back

Understanding and overcoming innate and acquired MAPK-inhibition resistance in anaplastic thyroid cancer

2024-12-05 oncology Title + abstract only
View on medRxiv
Show abstract

Anaplastic thyroid cancer (ATC) is one of the most lethal human cancers, with some patients succumbing to the disease within weeks of diagnosis. Although a subset of patients with ATC with BRAFV600E mutation respond to the monomeric type I RAF inhibitor (RAFi) dabrafenib in combination with MEK inhibitor (MEKi) trametinib, most rapidly develop adaptive or acquired resistance. These patients, along with those who do not harbor the BRAFV600E alteration, have limited treatment options. To understan...

Predicted journal destinations

1
Nature Communications
483 training papers
Top 3% 17.7%
2
Cancers
57 training papers
Top 2% 11.8%
3
Clinical Cancer Research
22 training papers
Top 0.7% 6.4%
4
Frontiers in Oncology
34 training papers
Top 3% 6.0%
5
PLOS ONE
1737 training papers
Top 76% 6.0%
6
Cell Reports
25 training papers
#1 5.6%
7
eLife
262 training papers
Top 8% 5.0%
8
Scientific Reports
701 training papers
Top 67% 3.9%
9
Proceedings of the National Academy of Sciences
100 training papers
Top 4% 2.8%
10
British Journal of Cancer
22 training papers
Top 2% 2.1%
11
Nature Genetics
72 training papers
Top 6% 1.9%
12
International Journal of Cancer
18 training papers
Top 0.5% 1.9%
13
Cancer Medicine
17 training papers
Top 3% 1.9%
14
Cell Reports Medicine
49 training papers
Top 2% 1.9%
15
iScience
74 training papers
Top 5% 1.6%
16
The Journal of Clinical Endocrinology & Metabolism
26 training papers
Top 2% 1.3%
17
JAMA Network Open
125 training papers
Top 17% 1.3%
18
Genome Medicine
56 training papers
Top 6% 1.3%
19
BMC Cancer
21 training papers
Top 4% 1.3%
20
Nature
58 training papers
Top 5% 1.2%
21
Journal of Clinical Investigation
50 training papers
Top 4% 1.0%
22
PLOS Computational Biology
141 training papers
Top 12% 0.9%
23
Communications Biology
36 training papers
Top 3% 0.9%
24
Communications Medicine
63 training papers
Top 5% 0.9%
25
International Journal of Molecular Sciences
39 training papers
Top 7% 0.7%