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Parent-of-Origin inference and its role in the genetic architecture of complex traits: evidence from ~220,000 individuals
2024-12-05
genetic and genomic medicine
Title + abstract only
View on medRxiv
Show abstract
Parent-of-origin effects (POEs) occur when the impact of a genetic variant depends on its parental origin. Traditionally linked to genomic imprinting, these effects are believed to have evolved from parental conflict over resource allocation to offspring, which results in opposing parental genetic influences. Despite their potential importance, POEs remain heavily understudied in complex traits, largely due to the lack of parental genomes. Here, we present a multi-step approach to infer the par...
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