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Identification of Inhibitors of Chikungunya virus nsP2 ATPase

Navarro, H.; Scott, J. E.; Smith, G. R.; Ghiabi, P.; Gibson, E.; Loppnau, P.; Harding, R. J.; Hossain, M. A.; Bose, M. R.; Pearce, K. H.; Merten, E. M.; Willson, T. M.; Brown, P. J.

2024-12-02 biochemistry
10.1101/2024.12.02.625520 bioRxiv
Show abstract

Non-structural protein 2 (nsP2), which plays an essential role in replication of CHIKV, contains a protease, helicase, and methyltransferase-like domain. We executed a simple a screen using malachite green to detect compounds that decreased ATP hydrolysis and tested a library of diverse compounds to find inhibitors of CHIKV nsP2 helicase.

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