Striatal Astrocytes Influence Dopamine Dynamics and Behavioral State Transitions
Lazaridis, I.; Ahn, G. A.; Hirokane, K.; Choi, W.; Graybiel, A. M.
Show abstract
We demonstrate here that astrocytes in the striatum interact with striatal dopamine in bidirectional signaling with dopamine release actively driving surges in astrocytic Ca++, which in turn modulate and reduce subsequent dopamine release. These Ca++ surges accurately predict behavioral state changes from task-engaged to task-disengaged states, but fail to predict detailed action parameters. We propose that interactions between striatal astrocytes and dopamine are strong candidates to modulate nigro-striato-nigral loop function underlying on-going behavioral state dynamics.
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