The mycobacterial nucleoid-associated protein NapM exhibits stress-induced septal localization and modulates cell envelope gene expression
Milcarz, K.; Hołowka, J.; Pawełczyk, J.; Pasciak, M.; Lavrynchuk, Y.; Płocinski, P.; Zakrzewska-Czerwinska, J. Z.
Show abstract
The bacterial chromosome is organized in a hierarchical and dynamic manner to facilitate various DNA transactions. Nucleoid-associated proteins (NAPs) are the most abundant small-scale chromosomal organizers, playing roles in maintaining chromosomal DNA integrity, gene regulation, DNA replication, and DNA repair. In this study, we characterize the recently identified mycobacterial NAP, NapM in Mycobacterium smegmatis. Our study shows that NapM exhibits a distinctive septal localization in response to stress affecting cell envelope integrity and modulates the expression of approximately one-third of M. smegmatis genes, including those involved in cell envelope biosynthesis. Our findings suggest that NapM regulates mycobacterial cell division under stress, enabling this saprophyte to adapt to constantly changing environmental conditions.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- FhaA plays a key role in mycobacterial polar elongation and 1 asymmetric growth 98%
- The function of CozE proteins is linked to lipoteichoic acid biosynthesis in Staphylococcus aureus 97%
- Beyond self-resistance: ABCF ATPase LmrC is a signal-transducing component of an antibiotic-driven signaling cascade hastening the onset of lincomycin biosynthesis 96%
Similar papers in this journal
- A quorum sensing-regulated type VI secretion system containing multiple nonredundant VgrG proteins is required for interbacterial competition in Chromobacterium violaceum 96%
- Evaluation of the role of whiB6 and kdpDE in the dominant multidrug resistant clone Mycobacterium tuberculosis B0/W148 96%
- Lsr2, a pleiotropic regulator at the core of the infectious strategy of Mycobacterium abscessus 96%
Similar papers in this journal
- Unraveling proteomic chaos by independent component analysis - ClpX proficiency promotes the iron and oxygen limitation responses of Staphylococcus aureus and affects the intracellular bacterial behavior 97%
- A high content microscopy screening identifies new genes involved in cell width control in Bacillus subtilis 96%
- Complex interplay between gene deletions and the environment uncovers cellular roles for genes of unknown function in Escherichia coli 96%
Similar papers in this journal
- Secreted LysM proteins are required for niche competition and full virulence in Pseudomonas savastanoi during host plant infection 97%
- Environmental Regulation of Toxin Production in Bacillus anthracis 96%
- Intracellular Salmonella Paratyphi A is motile and differs in the expression of flagella-chemotaxis, SPI-1 and carbon utilization pathways in comparison to Intracellular S. Typhimurium 96%
Similar papers in this journal
- Intracellular glutamine fluctuates with nitrogen availability and regulates Mycobacterium smegmatis biofilm formation 97%
- The Gene Encoding Ornithine Decarboxylase for Putrescine Biosynthesis Is Essential for the Viability of Fusobacterium nucleatum 97%
- Pyrimidine sufficiency is required for Sae two-component system signaling in Staphylococcus aureus 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.