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Use of the test-negative design to estimate the protective effect of a scalar immune measure: A simulation analysis
2024-11-23
epidemiology
Title + abstract only
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BackgroundThe relationship between antibody levels (more generally, a scalar measure of immune protection) at the time of exposure to infection (so-called exposure-proximal correlates of protection) and the risk of infection given exposure is of central interest in evaluating the evolution of immune protection conferred by prior infection and/or vaccination. A version of the test-negative study design (TND), adapted from vaccine effectiveness studies, has been used to assess this relationship. H...
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