Long-Term Coronary Microvascular and Cardiac Dysfunction Following Severe COVID-19 Hospitalization

BackgroundCoronavirus disease 2019 (COVID-19) can lead to long-term cardiopulmonary symptoms and is associated to coronary microvascular dysfunction (CMD). However, long-term data on CMD following severe COVID-19 are lacking. ObjectiveTo determine long-term left ventricular (LV) function and presence of CMD after severe COVID-19, utilizing cardiovascular magnetic resonance (CMR) and stress perfusion mapping. MethodsHospitalized COVID-19 patients underwent CMR at 10 months follow-up (1.5T Aera, Siemens Healthineers) including cine imaging, native T1 and T2, extracellular volume, and adenosine stress perfusion mapping. Clinical data were obtained from patient records. Patients were compared to volunteers without symptomatic ischemic heart disease (IHD). ResultsCOVID-19 patients (n=37, age 56{+/-}12 years, 76% male) and volunteers (n=22, age 51{+/-}13 years, 55% male, p=ns for both) were included. COVID-19 patients demonstrated reduced stress perfusion (2.8{+/-}0.81 vs 3.4{+/-}0.69 ml/min/g, p=0.003), impaired global longitudinal strain (GLS, -17{+/-}2 vs -19{+/-}2 %, p=0.003) and global circumferential strain (GCS, -16{+/-}3 vs -19{+/-}3 %, p=0.001). There were no differences in stress perfusion or myocardial perfusion reserve between COVID-19 patients with or without cardiovascular risk factors or cardiac symptoms. ConclusionCOVID-19 patients exhibit long-term reduced stress perfusion indicating CMD, and impaired LV function by GLS and GCS. Lack of variation in stress perfusion between patients with and without cardiovascular risk factors suggests that CMD may be a consequence of severe COVID-19, warranting further investigation to elucidate mechanisms, and guide potential therapeutic interventions.