Plasma glycome reflects low back pain progression and is not predictive of acute-to-chronic pain transition
Elgaeva, E. E.; Trbojevic-Akmacic, I.; Ugrina, I.; Vilaj, M.; Slana, A.; Pribic, T.; Tsepilov, Y. A.; Karssen, L. C.; Aulchenko, Y. S.; Dagostino, C.; Allegri, M.; Skelin, A.; Primorac, D.; Buyse, K.; Van Zundert, J.; Lauc, G.; Williams, F. M. K.; Freidin, M. B.
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AimsTo investigate if the plasma N-glycome would provide a biomarker of acute-to-chronic low back pain (LBP) transition. Patients & MethodsA prospective longitudinal sample of n = 1,114 individuals enrolled at the first ever episode of LBP and followed-up for three months. Total plasma N-glycome was measured and compared at the baseline and follow-up. ResultsInitial pro-inflammatory patterns of plasma N-glycome change to normal levels between baseline and follow-up in those who resolved from LBP, but not in those who remained at pain after three months. Baseline levels of N-glycans were not predictive of the risk of chronic LBP at follow-up. ConclusionTotal plasma N-glycan levels may reflect ongoing inflammation that is aberrant and promotes ongoing pain and chronicity of symptoms.
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