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Non-invasive Preimplantation Genetic Testing of Embryonic Genome in Spent Culture Medium

2024-11-13 genetic and genomic medicine Title + abstract only
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Traditionally, preimplantation genetic testing (PGT) for in vitro fertilization (IVF) requires invasive trophectoderm (TE) biopsy, which might be detrimental to the embryo. Recently proposed non-invasive PGT (ni-PGT) utilizing cell-free DNA from spent embryo culture medium (SCM) also faces serious challenges in accuracy, especially for monogenic diseases (niPGT-M), due to trace DNA content, maternal cell contamination, and high Allele Drop-Out (ADO) rates. In this study, an improved linear singl...

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