Hormonal contraceptive intake during adolescence and cortical brain measures in the ABCD Study
Heller, C.; Dhamala, E.; Bottenhorn, K. L.; Herting, M.; Bosse, B.; De La Rosa, J. S.; Farland, L. V.; Allen, A.; Barth, C.; Petersen, N.
Show abstract
Adolescence is a critical period in human development, marked by rapid changes in brain structure and function, influenced, in part, by sex steroids. During adolescence, females may initiate the use of hormonal contraception, which suppresses ovarian production of estradiol and progesterone. Here, we examined the impact of hormonal contraceptive use on adolescent brain structures using magnetic resonance imaging data from 1,234 individuals from the ABCD Study (average age = 14 years). We investigated differences in cortical thickness, surface area, and volume in hormonal contraceptive-users compared to non-users. Statistically significant differences were observed in several regions, and differences in cortical thickness of the paracentral gyrus survived familywise error correction. Estradiol, testosterone and DHEA levels negatively correlated with cortical thickness, surface area, and volume across both hormonal contraceptive-users and non-users only at an uncorrected threshold. These findings highlight the need to further study longitudinal effects of hormonal contraceptives and endogenous hormone changes on brain development in the ABCD Study and related datasets as these data become available.
Matching journals
The top 5 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The Sex-Specific Role of Adrenal Androgens in Youth Psychopathology 94%
- Genetic polymorphism of CYP2C19 and subcortical variability in the human adult brain 92%
- Investigating resting brain perfusion abnormalities and target-engagement by intranasal oxytocin in women with bulimia nervosa and binge-eating disorder and healthy controls 92%
Similar papers in this journal
- Puberty differentially predicts brain maturation in males and females during early adolescence: A longitudinal ABCD Study 94%
- A Multidimensional Approach to Understanding the Emergence of Sex Differences in Internalizing Symptoms in Adolescence 92%
- Puberty contributes to adolescent development of fronto-striatal functional connectivity supporting inhibitory control 92%
Similar papers in this journal
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.