Systematic review and meta-analysis of bulk RNAseq studies in human Alzheimer's disease brain tissue
Heberle, B. A.; Fox, K. L.; Libermann, L. L.; Xavier, S. R. M.; Dallarosa, G. T.; Santos, R. C.; Fardo, D. W.; Viola, T. W.; Ebbert, M. T. W.
Show abstract
ObjectiveTo systematically review and meta-analyze bulk RNA sequencing studies comparing Alzheimers disease (AD) patients with controls in human brain tissue, assessing study quality and identifying key genes and pathways. MethodsWe searched PubMed, Web of Science, and Scopus on September 23, 2023, for studies using bulk RNAseq on primary human brain tissue from AD patients and controls. Excluded were non-primary tissue, re-analyses without new data, limited RNA types and gene panels. Quality was assessed with a 10-category tool. Meta-analysis used high-quality datasets. ResultsFrom 3,266 records, 24 studies met criteria. Meta-analysis found 571 differentially expressed genes (DEGs) in temporal lobe and 189 in frontal lobe; overlapping pathways included "Tube morphogenesis" and "Neuroactive ligand-receptor interaction." LimitationsStudy heterogeneity and limited data tables constrained the review. ConclusionsRigorous methods are vital in AD transcriptomic studies. Findings enhance understanding of transcriptomic changes, aiding biomarker and therapeutic development. RegistrationPROSPERO (CRD42023466522).
Matching journals
The top 4 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Frequency of Variants in Mendelian Alzheimer’s Disease Genes within the Alzheimer’s Disease Sequencing Project (ADSP) 95%
- Targeted Serum Metabolomic Profiling and Machine Learning Approach in Alzheimer’s Disease using the Alzheimer’s Disease Diagnostics Clinical Study (ADDIA) Cohort 94%
- Neural mechanisms of disease pathology and cognition in young-onset Alzheimer’s Disease variants 94%
Similar papers in this journal
- African Ancestry GWAS of Dementia in a Large Military Cohort Identifies Significant Risk Loci 97%
- Integrative Brain Transcriptome Analysis Links Complement Component 4 and HSPA2 to the APOE ε2 Protective Effect in Alzheimer Disease 96%
- Region-based analysis of rare genomic variants in whole-genome sequencing datasets reveal two novel Alzheimer’s disease-associated genes: DTNB and DLG2 95%
Similar papers in this journal
Similar papers in this journal
- Association of RDoC dimensions with post-mortem brain transcriptional profiles in Alzheimer’s Disease 95%
- Cross-sectional study of plasma phosphorylated Tau 217 in persons without dementia 95%
- Evaluation of a speech-based AI system for early detection of Alzheimer’s disease remotely via smartphones 94%