Data Resource Profile: Genomic Data in Multiple British Birth Cohorts (1946-2001) - Health, Social, and Environmental Data from Birth to Old Age
Shireby, G.; Morris, T. T.; Wong, A.; Chaturvedi, N.; Ploubidis, G. B.; Fitzsimmons, E.; Goodman, A.; Sanchez-Galvez, A.; Davies, N. M.; Wright, L.; Bann, D.
Show abstract
Birth cohort studies have a rich history of contributing to science across disciplinary fields, notably health and social sciences. Here, we introduce a curated resource comprising genomic data from five British birth cohort studies--longitudinal studies with extensive data collected prospectively across life, each deliberately sampled to be nationally representative (born 1946-2001). These contain health and social data from birth to older age, enabling longitudinal and cross-cohort genetically informed research. The Millennium Cohort Study additionally includes data on parents and offspring, enabling within-family analyses. Across five cohorts born in 1946, 1958, 1970, 1989-90, and 2000-2002, 27,432 participants have harmonized, imputed, and quality-controlled genetic data from genotyping arrays covering 6.7 million common SNPs. The Millennium Cohort Study contains over 6,000 mother-offspring pairs and over 3,000 mother-father-offspring trios. Pseudonymized data are freely available to the global research community upon approval of a data access request (https://cls.ucl.ac.uk/data-access-training).
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