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Consolidation of sequential experience into a deep generative network explains human memory, prediction and planning

Spens, E.; Burgess, N.

2025-04-27 neuroscience
10.1101/2024.11.04.621950 bioRxiv
Show abstract

Many cognitive functions involve interplay between episodic (hippocampal) and semantic (neocortical) systems, but the mechanisms are unclear. We present a computational model in which sequential experiences are encoded in hippocampus in compressed form and replayed to train a neocortical generative network. This network captures the gist of specific episodes and extracts statistical patterns that generalise to new situations, enabling efficient reconstruction of the past and prediction of the future. The two systems interact during recall and prediction, with the hippocampus retrieving relevant episodic information into working memory as a basis for generation using the general knowledge of the neocortical network. We simulate this interaction as retrieval-augmented generation, with the addition of mechanisms to compress episodic memories into hippocampus and to consolidate them into neocortex. The model explains changes to memories over time, including schema-based distortions, and shows how recent episodic and semantic memory contribute to new problem solving.

Published in Nature Communications (predicted rank #4) · training set

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