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The balanced lethal system in Triturus newts originated in an instantaneous speciation event.

France, J. M.; de Visser, M. C.; Arntzen, J. W.; Babik, W.; Cvijanovic, M.; Ivanovic, A.; Smith, J.; Vuicc, T.; Wielstra, B.

2025-01-30 evolutionary biology
10.1101/2024.10.29.620207 bioRxiv
Show abstract

Triturus newts are afflicted by a balanced lethal system causing the spontaneous death of half of their offspring. How could such a maladaptive trait evolve? We construct genetic maps for Triturus and its sister genus Lissotriton, identifying genes involved in the balanced lethal system. Triturus chromosome 1 has diverged into two versions, which each carry a single massive deletion that is compensated for by duplication of the same region in the alternate version - indicating that the balanced lethal system arose instantaneously, in a single macromutation. Simulations show that, counterintuitively, the deleterious nature of the rearranged chromosomes protects them against competition with the ancestral arrangement via reproductive isolation. We conclude that the origin of the Triturus balanced lethal system also led to instantaneous speciation.

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