Back

Multimodal Hyperbolic Graph Learning for Alzheimer's Disease Detection

Xie, C.; Zhou, W.; Peng, C.; Hoshyar, A. N.; Xu, C.; Naseem, U.; Xia, F.

2024-11-04 public and global health
10.1101/2024.10.29.24316334 medRxiv
Show abstract

Multimodal graph learning techniques have demonstrated significant potential in modeling brain networks for Alzheimers disease (AD) detection. However, most existing methods rely on Euclidean space representations and overlook the scale-free and small-world properties of brain networks, which are characterized by power-law distributions and dense local clustering of nodes. This oversight results in distortions when representing these complex structures. To address this issue, we propose a novel multimodal Poincare Frechet mean graph convolutional network (MochaGCN) for AD detection. MochaGCN leverages the exponential growth characteristics of hyperbolic space to capture the scale-free and small-world properties of multimodal brain networks. Specifically, we combine hyperbolic graph convolution and Poincare Frechet mean to extract features from multimodal brain networks, enhancing their rep-resentations in hyperbolic space. Our approach constructs multimodal brain networks by integrating information from diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) data. Experiments on the Alzheimers Disease Neuroimaging Initiative (ADNI) dataset demonstrate that the proposed method outperforms state-of-the-art techniques.

Matching journals

The top 10 journals account for 50% of the predicted probability mass.

50% of probability mass above

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.