Mu opioid receptor expression by nucleus accumbens inhibitory interneurons promotes affiliative social behavior
Toddes, C.; Lefevre, E. M.; Retzlaff, C. L.; Zugschwert, L.; Khan, S.; Myhre, E.; Gauthier, E. A.; Fernandez de Velasco, E. M.; Kieffer, B. L.; Rothwell, P. E.
Show abstract
Mu opioid receptors in the nucleus accumbens regulate motivated behavior, including pursuit of natural rewards like social interaction as well as exogenous opioids. We used a suite of genetic and viral strategies to conditionally delete mu opioid receptor expression from all major neuron types in the nucleus accumbens. We pinpoint inhibitory interneurons as an essential site of mu opioid receptor expression for typical social behavior, independent from exogenous opioid sensitivity.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- USP7/Maged1-Mediated H2A Monoubiquitination in the Paraventricular Thalamus: An Epigenetic Mechanism Involved in Cocaine Use Disorder 97%
- Impaired bidirectional communication between interneurons and oligodendrocyte precursor cells affects cognitive behavior 96%
- Egr1 is a sex-specific regulator of neuronal chromatin, synaptic plasticity, and behaviour 96%
Similar papers in this journal
Similar papers in this journal
- Mating activates neuroendocrine pathways signaling hunger in Drosophila females 97%
- linc-mipep and linc-wrb encode micropeptides that regulate chromatin accessibility in vertebrate-specific neural cells 97%
- Slowly evolving dopaminergic activity modulates the moment-to-moment probability of movement initiation. 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.