Comparative modeling of fetal exposure to maternal long-acting injectable versus oral daily antipsychotics

2024-10-23 pharmacology and therapeutics Title + abstract only

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This study employed physiologically based pharmacokinetic (PBPK) modelling to compare the extent of fetal exposure between oral and long-acting injectable (LAI) aripiprazole and olanzapine. Adult and pregnancy PBPK models were developed and validated with relevant clinical data. Relevant indices of fetal exposure during pregnancy were predicted from concentration-time data at steady-state dosing for both oral and LAI formulations. Fetal Cmax for aripiprazole was 59-78% higher with LAI than oral,...

Comparative modeling of fetal exposure to maternal long-acting injectable versus oral daily antipsychotics

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