Back

Traumatic Microhemorhages Are Not Synonymous With Axonal Injury

Mittenzwei, R.; Maioli, H.; Sytsma, K.; Kirkland, A.; Keene, C. D.; Diaz-Arrastia, R.; Mac Donald, C.; Maffei, C.; Edlow, B. L.; Nolan, A.

2024-10-22 neurology
10.1101/2024.10.21.24315697 medRxiv
Show abstract

Diffuse axonal injury (DAI) is caused by acceleration-deceleration forces during trauma that shear white matter tracts. Susceptibility-weighted MRI (SWI) identifies microbleeds that are considered the radiologic hallmark of DAI and are used in clinical prognostication. However, this assumption is limited by a lack of systematic radiologic-pathologic correlation studies. Here, we performed ex vivo SWI on three brains from patients who died after severe TBI and assessed axonal injury around SWI microbleeds using immunohistochemistry to the amyloid beta precursor protein. Axonal injury was present in 28/44 microbleeds (64%), undermining the assumed pathophysiologic 1:1 link between traumatic vascular and axonal injury.

Matching journals

The top 5 journals account for 50% of the predicted probability mass.

1
Neurology
○ 50 papers in training set
Top 0.1%
18.2%
Similar papers in this journal
2
Journal of Neurotrauma
○ 31 papers in training set
Top 0.1%
11.7%
Similar papers in this journal
3
Brain Communications
◐ 166 papers in training set
Top 0.3%
9.5%
Similar papers in this journal
4
Frontiers in Neurology
○ 102 papers in training set
Top 0.3%
8.8%
Similar papers in this journal
5
Annals of Neurology
○ 64 papers in training set
Top 0.3%
5.4%
Similar papers in this journal
50% of probability mass above
6
Acta Neuropathologica Communications
○ 89 papers in training set
Top 0.4%
4.8%
7
Neurocritical Care
○ 12 papers in training set
Top 0.1%
4.3%
8
Annals of Clinical and Translational Neurology
○ 34 papers in training set
Top 0.2%
4.3%
9
Journal of the Neurological Sciences
○ 18 papers in training set
Top 0.1%
3.2%
10
Stroke
○ 40 papers in training set
Top 0.5%
2.4%
11
Brain
◐ 168 papers in training set
Top 2%
2.4%
12
Journal of Neurology
○ 28 papers in training set
Top 0.4%
2.1%
13
Journal of Neurology, Neurosurgery & Psychiatry
● 30 papers in training set
Top 0.3%
1.9%
14
NeuroImage: Clinical
○ 144 papers in training set
Top 2%
1.7%
15
Movement Disorders
○ 71 papers in training set
Top 0.6%
1.1%
16
Scientific Reports
○ 3612 papers in training set
Top 65%
1.1%
17
Acta Neuropathologica
○ 58 papers in training set
Top 1%
1.0%
18
Human Brain Mapping
○ 329 papers in training set
Top 4%
0.8%
19
Alzheimer's & Dementia
177 papers in training set
Top 2%
0.6%
20
Neurosurgery
○ 11 papers in training set
Top 0.4%
0.6%
21
Experimental Neurology
○ 61 papers in training set
Top 2%
0.6%
22
Biomedical Optics Express
● 95 papers in training set
Top 1%
0.6%
23
Nature Communications
○ 5641 papers in training set
Top 59%
0.6%
24
Frontiers in Neuroscience
○ 256 papers in training set
Top 7%
0.6%
25
Biomedicines
○ 67 papers in training set
Top 4%
0.6%
26
Multiple Sclerosis Journal
○ 21 papers in training set
Top 0.2%
0.6%

"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.