Connectomic Organization of the Suprachiasmatic Nucleus
Liu, J.; Yu, J.; Shen, L.; Chen, X.; Ma, L.; Zhai, H.; Li, L.; Zhang, L.; Wang, L.; Yuan, J.; Chen, B.; Hong, B.; Liu, J.; Lv, Y.; Cai, Y.; Zhang, Y.; Chang, S.; Guo, J.; Chen, H.; Liu, M.; Wang, Z.; Xin, T.; Zhou, F.; Zhao, X.; Zhang, D.; Xie, Q.; Ma, H.; Xu, Y.; Cheng, H.; Han, H.
Show abstract
The suprachiasmatic nucleus (SCN), the mammalian master clock, is a special structure dedicated to the time computation. However, a connectomic understanding of the nucleus as a whole is lacking. Using serial section electron microscopy, we reconstructed multiscale and multimodal SCN communication networks. Intra-SCN synaptic network consists of 9,566 morphologically similar neurons and 4.3 million synapses, organized into multiscale circuitries that interact with SCN-traversing axon fascicles. Strikingly, SCN neurons engage in unique soma-soma ephaptic interaction, forming 2,038 electrotonic integrative units with the largest overlapping the light-responsive area (LRA). SCNs paracrine modality contains 47,396 m3 dense core vesicles, with notable scarcity in the LRA, suggesting cross-modal coordination and functional integration. These distinct network features provide comprehensive insights into the system architecture of the mammalian circadian clock.
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