Pre-existing intratumoral stem-like CD8+ T-cells drive radiotherapy-induced tumor control
Koksal, H.; Herbst, M.; Pereira, P.; Nater, M.; Regli, N.; Boudjeniba, C.; Erdem Borgoni, N.; Cecconi, V.; van den Broek, M.
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CD8+ T-cells are essential for spontaneous and therapy-induced restriction of tumor progression. Upon radiotherapy, these pre-existing CD8+ T-cells expand rapidly after their initial decline and are essential and sufficient for early tumor control. Stem-like CD8+ T-cells proliferate and differentiate into effector CD8+ T-cells in response to radiotherapy and are thus key determinants of therapy efficacy. Our findings highlight the critical role of intratumoral stem-like CD8+ T-cells in driving radiotherapy-induced anti-tumor immunity. Our study provides deeper insights into the dynamic behavior of CD8+ T-cells and their critical involvement in tumor control following radiotherapy.
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