Micro-RNA 7975 directly regulates MDTH expression and mediates endothelial cell proliferation and migration in the development of early atherosclerosis
Karere, G.; Wagner, N.
Show abstract
Cardiovascular disease (CVD) is commonly due to the development of atherosclerosis. Endothelial integrity is critical in the prevention of pathogenesis of atherosclerosis. The key to prevention of CVD is understanding the molecular mechanisms responsible for initiation of early atherosclerosis. MiRNAs are mediators of endothelial homeostasis, and their dysregulation could lead to early atherosclerotic disorder. We previously revealed the expression of miR-7975 in early atherosclerotic lesions. The aim of this study was to investigate the novel roles of miR-7975 on endothelial cell proliferation and migration, and in the regulation of metadherin (MTDH) expression. We performed proliferation and migration assays coupled with luciferase assay. We show that miR-7975 promotes proliferation and migration of endothelial cells and that miR-7976 directly regulates (MTDH), previously associated with cancer pathogenesis. In conclusion our results show miR-7975 could be a potential mediator of endothelial homeostasis and that MTDH is a novel target of miR-7975.
Matching journals
The top 11 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- The LEPIS-HuR-TMOD4 axis regulates hepatic cholesterol homeostasis and accelerates atherosclerosis 93%
- NOD1 ligand FK565 promotes atherogenesis and accumulation of NOD1high smooth muscle cells in atherosclerotic lesions 92%
- Enhancement of High-Density Lipoprotein-Associated Protease Inhibitor Activity Prevents Atherosclerosis Progression 91%
Similar papers in this journal
- Calcium dobesilate reduces VEGF signaling by interfering with heparan sulfate binding site and protects from vascular complications in diabetic mice 93%
- The up-regulation of TGF-beta1 by miRNA-132-3p/WT1 is involved in inducing leukemia cells to differentiate into macrophages 93%
- Relationship between epicardial and perivascular fatty tissue and adipokine-cytokine level in coronary artery disease patients 93%
Similar papers in this journal
- New insights into TNFα/PTP1B and PPARγ pathway through RNF213- a link between inflammation, obesity, insulin resistance and Moyamoya disease 94%
- Investigating Coronary Artery Disease methylome through targeted bisulfite sequencing 93%
- Global transcriptome analysis reveals partial estrogen-like effects of karanjin in MCF-7 breast cancer cells 92%
Similar papers in this journal
- Simvastatin mediates inhibition of exosome synthesis, localization, and secretion via multicomponent interventions. 93%
- Novel insights into the regulation of chemerin expression: role of acute-phase cytokines and DNA methylation 92%
- Effect of caffeine and other xanthines on liver sinusoidal endothelial cell ultrastructure 92%
Similar papers in this journal
- Modelling the effects of PPARβδ of innate inflammatory responses in lung tissues 93%
- From miRNA target gene network to miRNA function: miR-375 might regulate apoptosis and actin dynamics in the heart muscle via Rho-GTPases-dependent pathways 93%
- Vasa vasorum lumen narrowing in brain vascular hyalinosis in systemic hypertension patients with ischemic stroke 93%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.