Estimating the rate of sexual reproduction and the inbreeding rate in Leishmania
Nicoll, A. G.; Kilford, H.; Grace, C. A.; Reis-Cunha, J. L.; Jeffares, D. C.; Constable, G. W. A.
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Many eukaryotic species undergo sexual reproduction facultatively, either in response to stress or in particular environments. For the remainder of their life cycle they reproduce by mitosis. This facultative sex may be rare, which alters features of their evolutionary dynamics. Both the frequency of sex and the degree of inbreeding have been challenging to estimate from genome-scale polymorphism data. Here, we describe a method to estimate both these parameters based on the Moran model of heterozygous sites. We apply this method to population genomic data from Leishmania parasitic protozoans from the Leishmania donovani species complex, showing that these parasites undergo sexual reproduction approximately once per 10,000 generations and that populations vary considerably in the extent of their inbreeding.
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