Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2
Vecchiarelli, H. A.; Bisht, K.; Sharma, K. P.; Weiser Novak, S.; Traetta, M. E.; Garcia-Segura, M. E.; St-Pierre, M.-K.; Savage, J. C.; Willis, C.; Picard, K.; Bordeleau, M.; Vernoux, N.; Khakpour, M.; Garg, R.; Loewen, S. M.; Murray, C. J.; Grinberg, Y. Y.; Faustino, J.; Halvorson, T.; Lau, V.; Pluchino, S.; Vexler, Z. S.; Carson, M. J.; Manor, U.; Peruzzotti-Jametti, L.; Tremblay, M.-E.
Show abstract
This study examined dark microglia--a state linked to central nervous system pathology and neurodegeneration--during postnatal development in the mouse ventral hippocampus, finding that dark microglia interact with blood vessels and synapses and perform trogocytosis of pre-synaptic axon terminals. Furthermore, we found that dark microglia in development notably expressed C-type lectin domain family 7 member A (CLEC7a), lipoprotein lipase (LPL) and triggering receptor expressed on myeloid cells 2 (TREM2) and required TREM2, differently from other microglia, suggesting a link between their role in remodeling during development and central nervous system pathology. Together, these results point towards a previously under-appreciated role for dark microglia in synaptic pruning and plasticity during normal postnatal development.
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