Comparison of nasopharyngeal swab and oral fluid collected by ORACOL Saliva Collection System for molecular detection of SARS-CoV-2
Barbezange, C.; Hutse, V.; Roukaerts, I.; Thomas, I.; Tobback, E.; Callens, S.; De Scheerder, M.-A.; Padalko, E.
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The performance of Oracol collection device (Oracol) for oral fluid sampling for SARS-CoV-2 molecular detection was compared to nasopharyngeal swabs (NPS). Samples (n = 128) were collected from symptomatic and asymptomatic adults after PCR confirmed COVID-19 on NPS. All samples were tested by 3 real-time PCRs (RT-qPCR) for E, N and RdPR genes. Accuracy of Oracol compared to NPS was 38.28 % for E-gene, 47.66 % for RdRp-gene and 83.59 % for N-gene. A clear correlation between the N-gene Ct values on NPS and on Oracols was observed (p < 0.001). The sensitivity of the Oracol compared to the NPS increased in participants with an N-gene Ct value <30 on NPS (89.08%,) reaching 93.2 % with a N-gene Ct value <25. Oracol can be considered an alternative to NPS to detect SARS-CoV-2, especially in populations where NPS is not well tolerated.
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