Presynaptic filopodia form kinapses and modulate membrane mechanics for synchronous neurotransmission and seizure generation.
Jain, A.; Kroll, J.; Webster, J. F.; Moss, J.; Ultanir, S. K.; Gonzalez-Sulser, A.; Rosenmund, C.; Cousin, M. A.; Ivanova, D.
Show abstract
The structural stability of synapses directly contrasts with their functional plasticity. This conceptual dichotomy is explained by the assumption that all synaptic plasticity is generated via either electrical and/or biochemical signaling. Here, we challenge this dogma by revealing an activity-dependent presynaptic response that is physical in nature. We show that dynamic filopodia emerge during action potential discharge and transiently deform synaptic boutons to enhance connectivity. Filopodia generation requires neuronal activity, calcium and actin, and occurs in intact brain circuits and human brain. Mechanistically, their extension preserves synchronous neurotransmitter release by increasing presynaptic membrane tension. However, filopodia generation becomes maladaptive during dysregulated brain activity, exacerbating seizures in vivo. Therefore, we provide direct evidence that presynaptic mechanical forces determine the extent and timing of synaptic signals.
Matching journals
The top 3 journals account for 50% of the predicted probability mass.
Similar papers in this journal
- Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo 97%
- Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons 97%
- Brain-wide genetic mapping identifies the indusium griseum as a prenatal and shared target of pharmacologically-unrelated psychostimulants 96%
Similar papers in this journal
Similar papers in this journal
- Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer 97%
- Tomosyns attenuate SNARE assembly and synaptic depression by binding to VAMP2-containing template complexes 96%
- Molecular mechanics underlying flat-to-round membrane budding in live secretory cells 96%
Similar papers in this journal
- Synaptotagmin 7 is enriched at the plasma membrane to promote vesicle docking and control synaptic plasticity 97%
- Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses 97%
- Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex 96%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.