Autophagy, the Ubiquitin proteasome system, and the MAPK pathway control the temperature dependence of synaptic growth.
De Leon, K.; Marie, B.
Show abstract
There is clear evidence that Earths temperature is rising at an unprecedented rate. While consequences on ecosystems are being extensively studied, little is known about the consequences of temperature on the nervous system of ectothermic animals. Here we used the Drosophila model NMJ to assess the effect of temperature on the synaptic growth of a phasic, and a tonic, motoneuron. We find that the tonic neurons synaptic size is not affected by temperature, however we do observe a temperature-dependent synaptic growth in the phasic neuron, which might be related to the increased motility observed previously at higher temperatures. We find that the level of autophagy activity changes with temperature and that autophagy genes are responsible for the temperature dependence of synaptic growth. We present evidence that this regulation could occur through the major synaptic growth regulator and ubiquitin ligase Highwire, and a pathway involving the Mitogen-Activated Protein Kinases. We present a new function for the MAPKKK, Wallenda and the MAPK P38b in directing the additional synaptic growth that takes place between 25{degrees}C and 29{degrees}C. This illustrates that temperature has different effects on a diverse population of neurons and that distinct genetic pathways are involved in regulating temperature driven changes.
Matching journals
The top 6 journals account for 50% of the predicted probability mass.
Similar papers in this journal
Similar papers in this journal
- Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila 95%
- Drosophila Synaptotagmin 7 negatively regulates synaptic vesicle fusion and replenishment in a dosage-dependent manner 95%
- Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms 95%
Similar papers in this journal
Similar papers in this journal
- Antagonistic Regulation of Circadian Output and Synaptic Development by the E3 Ubiquitin Ligase JETLAG and the DYSCHRONIC-SLOWPOKE Complex 94%
- Tet Controls Axon Guidance in Early Brain Development through Glutamatergic Signaling 94%
- Evolutionary Adaptations of TRPA1 Thermosensitivity and Skin Thermoregulation in Vertebrates 94%
Similar papers in this journal
- CASK and FARP localize two classes of post-synaptic ACh receptors thereby promoting cholinergic transmission 95%
- CREB mediates the C. elegans dauer polyphenism through direct and cell-autonomous regulation of TGF-β expression 95%
- Choline Transporter regulates olfactory habituation via a neuronal triad of excitatory, inhibitory and mushroom body neurons 94%
"Similar papers" are the closest papers from that journal in the model's embedding space. They show what the match is built on, but the ranking comes mostly from a classifier over the whole training set, not from these examples alone.