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Regressing Away Common Neural Choice Signals does not make them Artifacts. Comment on Frömer et al (2024, Nature Human Behaviour)

O'Connell, R. G.; Corbett, E. A.; Pares-Pujolras, E.; Feuerriegel, D.; Kelly, S. P.

2024-09-27 neuroscience
10.1101/2024.09.26.614447 bioRxiv
Show abstract

Fromer et al (2024, Nature Human Behaviour) apply a deconvolution method to correct for component overlap in the event-related potential. They report that this method eliminates signatures of sensory evidence accumulation from response-aligned measurements of the centro-parietal positivity (CPP), suggesting that these signatures arise artifactually.. Here, we argue that the analysis and interpretation of their perceptual choice data are critically flawed. We demonstrate with simulations that the deconvolution analyses used by the authors are not designed to reliably test for the presence or absence of bounded accumulation signals.

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