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Bidirectional genetic and phenotypic links between smoking and striatal iron content involving dopaminergic and inflammatory pathways
2024-09-27
addiction medicine
Title + abstract only
View on medRxiv
Show abstract
Tobacco smoking is a major modifiable risk factor for cardiovascular and lung diseases. A better understanding of its neurobiological underpinnings will benefit the prevention of smoking-related illnesses and mortality. Recent neuroimaging studies have identified a correlation between smoking and iron concentration in the brains striatum, a subcortical region involved in habit formation and compulsive behaviour, and a central node of dopamine activity. Moreover, iron accumulation in the striatum...
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