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Single Versus Repeated Intravenous Oncolytic Virus Infusions: Implications for Rationalised Scheduling of Therapy in Hepatocellular Carcinoma.
2024-09-27
oncology
Title + abstract only
View on medRxiv
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Scheduling of oncolytic virus (OV) therapy has never been correlated with immunological /clinical response. In hepatocellular carcinoma (HCC) patients, where background liver is frequently chronically injured, repeated dosing may have deleterious implications, resulting in off-target immune-mediated damage, thereby tipping the balance between favourable clinical response and hepatotoxicity. Elucidation of the optimum dosing regime is paramount to ensure therapy, whilst limiting damage to backgro...
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