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Exploiting pleiotropy to enhance variant discovery with functional false discovery rates

2024-09-26 genetic and genomic medicine Title + abstract only
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The cost of acquiring participants for genome-wide association studies (GWAS) can limit sample sizes and inhibit discovery of genetic variants. We introduce the surrogate functional false discovery rate (sfFDR) framework which integrates summary statistics of related traits to increase power. The sfFDR framework provides estimates of FDR quantities such as the functional local FDR and q-value, and uses these estimates to derive a functional p-value for type I error rate control and a functional ...

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