Reduced Cortical Excitability is Associated with Cognitive Symptoms in Concussed Adolescent Football Players

BackgroundAmerican tackle football is associated with high rates of concussion, leading to neurophysiological disturbances and debilitating clinical symptoms. Previous investigations of the neurophysiological effects of concussion have largely ignored aperiodic neurophysiological activity, which is a marker of cortical excitability. PurposeWe examined whether concussion during a season of high school football is related to changes in aperiodic and periodic neurophysiological activity and whether any such changes are associated with clinical outcomes. Materials and MethodsPre- and post-season resting-state magnetoencephalography (MEG) data were collected from 91 high school football players over as many as four seasons of play, for a total of 278 data collections. During these seasons of football play, a cohort of 10 individuals were diagnosed with concussion. MEG data were source-imaged, frequency-transformed and parameterized, and linear mixed models were used to examine effects of concussion on pre-to-post-season changes in neurophysiological activity. Scores on the Post-Concussive Symptom Inventory were correlated with pre-to-post-season neurophysiological changes to determine their clinical relevance. ResultsConcussion was associated with increased aperiodic exponents in superior frontal cortices, indicating a relative reduction in cortical excitability. This slowing of aperiodic neurophysiology mediated concussion effects on raw delta and gamma power and was associated with worse cognitive concerns across participants. Pre-to-post-season changes in aperiodic-corrected alpha and theta rhythmic activity were also decreased in posterior cortices in concussed players. ConclusionThese findings indicate that concussion alters both the excitability and rhythmic signaling of the cortex, with differing spatial topographies and implications for clinical symptoms. Key ResultsO_LIConcussion reduces cortical excitability in superior frontal cortices. C_LIO_LIThis reduction accounts for canonical effects of concussion on delta and gamma power. C_LIO_LIConcussion-related changes in cortical excitability are associated with increased cognitive symptom severity. C_LI